|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship.
|
30039188 |
2018 |
|
Memory impairment
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F<sub>3,93</sub> =5.568, P = .020).
|
29883038 |
2019 |
|
PARKINSON DISEASE, LATE-ONSET
|
|
0.010 |
GeneticVariation
|
BEFREE |
More genetic studies using large-sized and well-defined matched samples of AD and PD patients from mixed populations as well as functional correlation analysis are urgently needed to clarify the role of rs3851179 in the AD/PD risk.
|
28567584 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor.
|
28549650 |
2017 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The PICALM rs3851179 polymorphism significantly affects the DMN network in MCI.
|
28549650 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT.
|
28316001 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT.
|
28316001 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD.
|
28073596 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially.
|
27048444 |
2017 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".
|
26972434 |
2016 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD.
|
26889634 |
2016 |
|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD.
|
26889634 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The allele T of rs38</span>51179 in PICALM was associated with a 13 % increase in the risk of AD.
|
26611835 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
|
25359311 |
2015 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD.
|
25169757 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |